Nanomedicine Web Page by Elias Fattal

Lipoplexes targeting the CD 44 receptor

admin — Mon, 25 May 2009 22:34:05 +0000

We have introduced in lipoplexes a Hyaluronic acid-phospholipid conjugate. The modified lipoplexes were able to target specifically MDA-MB 231 cells expressing CD44 receptor. Transfection was blocked by antiCD44 antibody. This system open up interesting properties in the design of targeted delivery of DNA to cancer cells. If you want to know more

Perfluorooctyl Bromide Polymeric Capsules as Dual Contrast Agents for Ultrasonography and Magnetic Resonance Imaging

admin — Thu, 25 Sep 2008 22:26:52 +0000

In collaboration with Lori Bridal & Wladimir Urbach and Brigitte Gillet, with my young colleague Nicolas Tsapis, we have applied nanotechnologies containg pefluoroctylbromide previously described for ultrasound imaging and 19F MRI. An animal experiment carried out on nude mice show a stable image of nanocapsules of PFOB in the vena cava upon echography of the liver. Abstract and more…

Colonic delivery of beta lactamases does not affect amoxicillin pharmacokinetics in rats

admin — Wed, 05 Sep 2007 22:21:43 +0000

We have designed Pectin beads containing -lactamases for the hydrolysis of colonic residual antibiotics responsible for the emergence of resistance. In previous experiments, beads were shown to increase the level of active beta lactamases in the feces. We now show that release occurs only in the colon since no modification of the pharmacokinetics was shown in rat following simultaneous administration of beads containing the enzyme and amoxicillin Abstract and more…